Dynamic disorder in receptor-ligand forced dissociation experiments

Recently experiments showed that some biological noncovalent bonds increase their lifetimes when they are stretched by an external force, and their lifetimes will decrease when the force increases further. Several specific quantitative models have been proposed to explain the intriguing transitions from the "catch-bond" to the "slip-bond". Different from the previous efforts, in this work we propose that the dynamic disorder of the force-dependent dissociation rate can account for the counterintuitive behaviors of the bonds. A Gaussian stochastic rate model is used to quantitatively describe the transitions observed recently in the single bond P-selctin glycoprotein ligand 1(PSGL-1)$-$P-selectin force rupture experiment [Marshall, {\it et al.}, (2003) Nature {\bf 423}, 190-193]. Our model agrees well to the experimental data. We conclude that the catch bonds could arise from the stronger positive correlation between the height of the intrinsic energy barrier and the distance from the bound state to the barrier; classical pathway scenario or {\it a priori} catch bond assumption is not essential.Comment: 4 pages, 2 figure

The facilitated diffusion of oxygen by hemoglobin and myoglobin

We have clarified the use of Wyman's differential equation for the facilitated oxygen flux through a slab of solution of myoglobin or hemoglobin by showing that there is a unique choice of boundary condition on the carrier concentration to be employed in conjunction with it. The singular perturbation solution of Wyman's equation, due to Murrayand Mitchell and Murray, has been extended. By means of it, the paradox of Wittenberg, that the facilitated oxygen flux per mole of heme is apparently independent of the protein carrier, has been resolved

Corporate governance and sustainability practices: Evidence from Nigeria

This paper strives to explore the relationships between corporate governance (CG) and sustainability practices (SP): both two concepts have continued to draw attention due to their importance for the continued operation of businesses.In view of that, the paper seeks out to investigate the interrelationship between them using a sample of top oil companies in Nigeria. In-depth interviews were conducted with the management of the six oil companies in Nigeria. The interviews sought to elicit more information on corporate governance practices, ideas and opinion from the respondents on the sustainability practices.The interviews were based on both close-ended and open-ended questions and included questions about corporate governance and sustainability practices and the link between the two.The findings suggest that the popular view of the managers perceive CG as essential for sustainable development practices in businesses. The findings shows all the companies are into philanthropic social responsibility practices.The study suggests that the relationship between the two is overlapping as such there is need to exercise conscientious efforts on their agendas, though the finding is limited to a small sample size and it comes from one industr

Corporate governance and disclosure in Nigeria: An empirical study

This paper outlines a sample case study of ‘best practice’ as per the Nigerian 2011 code which can be adapted as role ‘model’.Oando PLC, one of the top 30 companies, is identified as the company which had complied with the Nigerian corporate governance code, in reference to transparency and internal control with “Excellent” performance.Similar to European codes, the Nigerian corporate governance codes are voluntary and listed companies are expected to comply with.This study explores the standard and quality of CG practices disclosed by Oando PLC, over the period 2010-2012, using the Nigerian 2011 Code as a benchmark

Asymptotics for the Wiener sausage among Poissonian obstacles

We consider the Wiener sausage among Poissonian obstacles. The obstacle is called hard if Brownian motion entering the obstacle is immediately killed, and is called soft if it is killed at certain rate. It is known that Brownian motion conditioned to survive among obstacles is confined in a ball near its starting point. We show the weak law of large numbers, large deviation principle in special cases and the moment asymptotics for the volume of the corresponding Wiener sausage. One of the consequence of our results is that the trajectory of Brownian motion almost fills the confinement ball.Comment: 19 pages, Major revision made for publication in J. Stat. Phy

Force Modulating Dynamic Disorder: Physical Theory of Catch-slip bond Transitions in Receptor-Ligand Forced Dissociation Experiments

Recently experiments showed that some adhesive receptor-ligand complexes increase their lifetimes when they are stretched by mechanical force, while the force increase beyond some thresholds their lifetimes decrease. Several specific chemical kinetic models have been developed to explain the intriguing transitions from the "catch-bonds" to the "slip-bonds". In this work we suggest that the counterintuitive forced dissociation of the complexes is a typical rate process with dynamic disorder. An uniform one-dimension force modulating Agmon-Hopfield model is used to quantitatively describe the transitions observed in the single bond P-selctin glycoprotein ligand 1(PSGL-1)$-$P-selectin forced dissociation experiments, which were respectively carried out on the constant force [Marshall, {\it et al.}, (2003) Nature {\bf 423}, 190-193] and the force steady- or jump-ramp [Evans {\it et al.}, (2004) Proc. Natl. Acad. Sci. USA {\bf 98}, 11281-11286] modes. Our calculation shows that the novel catch-slip bond transition arises from a competition of the two components of external applied force along the dissociation reaction coordinate and the complex conformational coordinate: the former accelerates the dissociation by lowering the height of the energy barrier between the bound and free states (slip), while the later stabilizes the complex by dragging the system to the higher barrier height (catch).Comment: 8 pages, 3 figures, submitte

Work probability distribution and tossing a biased coin

We show that the rare events present in dissipated work that enters Jarzynski equality, when mapped appropriately to the phenomenon of large deviations found in a biased coin toss, are enough to yield a quantitative work probability distribution for Jarzynski equality. This allows us to propose a recipe for constructing work probability distribution independent of the details of any relevant system. The underlying framework, developed herein, is expected to be of use in modelling other physical phenomena where rare events play an important role.Comment: 6 pages, 4 figures

Equality of averaged and quenched large deviations for random walks in random environments in dimensions four and higher

We consider large deviations for nearest-neighbor random walk in a uniformly elliptic i.i.d. environment. It is easy to see that the quenched and the averaged rate functions are not identically equal. When the dimension is at least four and Sznitman's transience condition (T) is satisfied, we prove that these rate functions are finite and equal on a closed set whose interior contains every nonzero velocity at which the rate functions vanish.Comment: 17 pages. Minor revision. In particular, note the change in the title of the paper. To appear in Probability Theory and Related Fields

Effect of Poisson ratio on cellular structure formation

Mechanically active cells in soft media act as force dipoles. The resulting elastic interactions are long-ranged and favor the formation of strings. We show analytically that due to screening, the effective interaction between strings decays exponentially, with a decay length determined only by geometry. Both for disordered and ordered arrangements of cells, we predict novel phase transitions from paraelastic to ferroelastic and anti-ferroelastic phases as a function of Poisson ratio.Comment: 4 pages, Revtex, 4 Postscript figures include

Ising models on power-law random graphs

We study a ferromagnetic Ising model on random graphs with a power-law degree distribution and compute the thermodynamic limit of the pressure when the mean degree is finite (degree exponent $\tau>2$), for which the random graph has a tree-like structure. For this, we adapt and simplify an analysis by Dembo and Montanari, which assumes finite variance degrees ($\tau>3$). We further identify the thermodynamic limits of various physical quantities, such as the magnetization and the internal energy